Clearing the Skies over Modular Polyketide Synthases
نویسندگان
چکیده
منابع مشابه
The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases.
Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis. In modular PKSs, the polyketide chain is assembled by the successive condensation of activated carboxylic acid-derived units, where chain extension occurs with the intermediates remaining covalently boun...
متن کاملHarnessing the Biosynthetic Potential of Modular Polyketide Synthases.
Although the structures of polyketide natural products have been (and continue to be) elucidated for over a century, the notion that a large subset of bacterial polyketides are synthesized through the action of modular polyketide synthases (PKSs) is less than a decade old. As described below, modular PKSs are large multifunctional enzyme assemblies that catalyze the controlled biosynthesis of t...
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Polyketides from actinomycete bacteria provide the basis for many valuable medicines, so engineering genes for their biosynthesis to produce variant molecules holds promise for drug discovery. The modular polyketide synthases are particularly amenable to this approach, because each cycle of chain extension is catalyzed by a different module of enzymes, and the modules are arranged within giant ...
متن کاملEmergent gene order in a model of modular polyketide synthases.
Polyketides are a class of biologically active heteropolymers produced by assembly line-like multiprotein complexes of modular polyketide synthases (PKS). The polyketide product is encoded in the order of the PKS proteins in the assembly line, suggesting that polyketide diversity derives from combinatorial rearrangement of these PKS complexes. Remarkably, the order of PKS genes on the chromosom...
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Polyketides are widespread, biologically active heteropolymers assembled by complexes of modular polyketide synthase(PKS) proteins. We implement a model of this system and explore its evolutionary behavior while subject to recombination in a changing environment. Under appropriate population parameters the combinatorial exploration of novelty allows a finite population to maintain high fitness ...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2006
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb600376r